Table 3.
Ventilatory Parameters
| Placebo (n = 15) | PBMT-sMF (n = 15) | Placebo vs PBMT-sMF | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | Day 10 | Endpoint | Baseline | Day 10 | Endpoint | Between Groups Comparisons | Mean Difference [95% CI] |
Effect Size Cohen d |
|
| Thickness fraction diaphragm (%) | 25.28 (± 12.85) | 22.90 (± 7.58) | 23.76 (± 13.15) | 29.55 (± 13.56) | 37.09 (± 17.02) | 44.22 (± 12.59)** | Baseline: p=0.99 Day 10: p=0.0117 Endpoint: p=0.0001 |
Baseline: 4.27 [−7.41 to 15.95] Day 10: 14.19 [2.50 to 25.87] Endpoint: 20.46 [8.77 to 32.14] |
Day 10: 1.1 (large) Endpoint: 1.6 (large) |
| PEEP (cmH2O) | 9.13 (± 2.64) | 8.93 (± 2.46) | 8.20 (± 4.09) | 9.00 (± 1.96) | 7.53 (± 2.82) | 6.60 (± 2.82) | Baseline: p=0.99 Day 10: p=0.5540 Endpoint: p=0.3931 |
Baseline: −0.13 [−2.69 to 2.43] Day 10: −1.40 [−3.96 to 1.16] Endpoint: −1.60 [- 4.16 to 0.96] |
Day 10: 0.5 (moderate) Endpoint: 0.5 (moderate) |
| PO2 (mmHg) | 91.46 (± 20.78) | 99.74 (± 29.93) | 92.74 (± 28.00) | 108.22 (± 29.68) | 106.46 (± 33.98) | 109.29 (± 26.16) | Baseline: p=0.99 Day 10: p=0.99 Endpoint: p=0.34 |
Baseline: 16.76 [−8.64 to 42.16] Day 10: 6.72 [−18.68 to 32.12] Endpoint: 16.55 [−8.85 to 41.95] |
Day 10: 0.2 (small) Endpoint: 0.6 (moderate) |
| FiO2 (%) | 69.66 (± 21.91) | 63.20 (± 26.72) | 75.46 (± 31.59) | 62.33 (± 21.03) | 51.26 (± 26.07) | 51.53 (± 29.68) | Baseline: p= 0.33 Day 10: p=0.6590 Endpoint: p=0.0456 |
Baseline: −7.33 [−30.92 to 16.26] Day 10: −11.94 [- 35.53 to 11.65] Endpoint:- 23.93 [−47.52 to −0.34] |
Day 10: 0.5 (moderate) Endpoint: 0.8 (large) |
| PO2/FiO2 (mmHg) | 146.71 (± 61.85) | 183.32 (± 81.85) | 158.26 (± 102.37) | 199.65 (± 109.82) | 261.28 (± 156.21) | 276.15 (± 163.07) | Baseline: p=0.67 Day 10: p=0.2246 Endpoint: p=0.0233 |
Baseline: 52.94 [−53.63 to 158.50] Day 10: 77.95 [−27.63 to 183.50] Endpoint: 117.90 [12.31 to 223.50] |
Day 10: 0.6 (moderate) Endpoint: 0.9 (large) |
Notes: **Intragroup difference (PBMT-sMF) compared to the baseline (p<0.01). Continuous variables are expressed as mean (SD).
Abbreviations: PBMT-sMF, photobiomodulation therapy combined with static magnetic field; PEEP, positive end-expiratory pressure levels; PO2, arterial partial pressure of oxygen; FiO2, fraction of inspired oxygen; PO2/FiO2, ratio of arterial partial pressure of oxygen and fraction of inspired oxygen.