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. 2021 Jul 24;14:3501–3521. doi: 10.2147/JIR.S312385

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© 2021 Zou et al.

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NLRP3 inflammasome formation in the lung. (A) Semiquantitative immunoblots reacted with anti-NLRP3, ASC, and caspase-1 antibodies, respectively. (B) Corresponding densitometric analyses of protein expression levels of NLRP3, ASC and caspase-1 normalized by β-actin. (n=3). Confocal microscopic analysis of NLRP3 inflammasome formation by examining NLPR3 colocalization with ASC or caspase-1 in the (C) alveoli and (E) bronchial wall of lung of mice receiving PPE or PBS instillation. (D and F) The Pearson correlation coefficient (PCC) for the colocalization of NLRP3 with ASC or caspase-1. (n=6). *P<0.05 vs PBS treatment.