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. 2021 Jul 24;14:3501–3521. doi: 10.2147/JIR.S312385

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© 2021 Zou et al.

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Inhibition of NLRP3 inflammasome formation and activation in acid sphingomyelinase (ASM) gene knockout mice receiving PPE instillation. Representative photomicrographs depicts NLPR3 colocalization with (A) ASC or (C) caspase-1. (B and D) Summarized data in the bar graph shows PCC. (E) Representative images depicts IL-1β immunostaining in the lung. (F) Summarized data shows IL-1β levels in different treatment groups. (n=6). *P<0.05 vs WT mice with PBS treatment. ^#P<0.05 vs WT mice with PPE treatment.