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. 2021 Jul 24;14:3375–3388. doi: 10.2147/DMSO.S315362

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© 2021 Tan et al.

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Interactions between angiogenic factors in diabetes mellitus and cancer. Hypoxia and hyperglycemia are the main characteristics of the microenvironment of tumor and diabetes mellitus. Hypoxia mainly promotes angiogenic factors, while hyperglycemia mainly inhibits them. VEGF, HIF-1, SDF-1, Ang-2, FGF and so on are the main factors affecting angiogenesis. EPCs, Pericytes, TAMS, CAFs, etc. These are the main cells involved in angiogenesis. These factors and cells are closely related to each other. It is the presence of these connections and pathways that account for the huge differences in angiogenesis between diabetes mellitus and tumors.