Table 4.
The validation results of other methods in comparison with this Kalman-Excel method for the determination of HCT and LSP in tablets.
| Sources | Method | Solvent | Range of concentration (μg/mL) HCT LSP |
LOD (μg/mL) HCT LSP |
LOQ (μg/mL) HCT LSP |
Rev (%) HCT LSP |
RSD (%) HCT LSP |
|---|---|---|---|---|---|---|---|
| [8] | PLS, spectrophotometry | H2O | 1.06–5.70 4.0–22.2 |
0.06 0.21 |
0.14 0.49 |
95.6 93.5 |
0.6 1.7 |
| [9] | 1/Vierordt's method 2/absorbance ratio method |
0.01N HCl | 0.563–27.27 0.708–22.22 |
0.233 0.708 |
0.186 0.563 |
98.13–99.69 | <0.246 |
| [10] | 1/simultaneous equation 2/ratio of absorbance 3/first-order derivative method |
Methanol | 1/1–20 5–25 2/1–25 5–80 3/1–40 1–30 |
0.5 | 1.97 | ≈99 | 0.57 |
| [11] | 1/simultaneous equation 2/dual wavelength 3/area under curve |
5–30 | 0.30 0.30 (3 methods) |
0.90 0.90 (3 methods) |
98.7–100.3 | 0.49–0.57 0.49–0.57 (3 methods) |
|
| [12] | Microemulsion liquid chromatography |
Mobile phase SDS, n-butanol, n-octane, water, and acetonitrile |
2.5–12.5 10.0–60.0 |
0.03 0.04 |
0.1 0.15 |
98.9 101 |
<1.4 |
| [13] | RP-HPLC | Acetonitrile and formic acid | 2–10 5–50 |
0.5 for HCT and LSP | 1.5 for HCT and LSP | 96 92 |
<0.61 <1.22 |
| [14] | RP-HPLC | Acetonitrile and formic acid | 1.0–300.3 4.4–240.2 |
0.304 0.232 |
0.921 0.734 |
99.55-100.67 98.44-100.48 |
0.24–0.61 0.19–1.22 |
| This study | Spectrophotometry with Kalman filter algorithm | H2O | 1.0–6.0 4.0–24.0 |
0.037 0.228 |
0.12 0.76 |
98.7–101.8 97.25–99.88 |
<0.167 for HCT and LSP |