Table 5.
Performance of Kalman-Excel method versus HPLC method to quantify HCT and LSP in Splozarsin Plus tablet simultaneously (n1 = n2 = 3).
| Amount of HCT in a tablet (mg/tablet) | Amount of LSP in a tablet (mg/tablet) | ||
|---|---|---|---|
| Kalman-Excel | HPLC | Kalman-Excel | HPLC |
| 12.4450 | 12.45 | 50.0825 | 49.93 |
| 12.4375 | 12.38 | 50.105 | 50.30 |
| 12.3825 | 12.42 | 49.855 | 50.45 |
| Mean = 12.422 ± 0.034 | Mean = 12.417 ± 0.035 | Mean = 50.014 ± 0.138 | Mean = 50.227 ± 0.268 |
| F exp = 1.059 | F exp = 3.745 | ||
| F (0.05; 2; 2) = 39.00 | F (0.05; 2; 2) = 39.00 | ||
| SDpool = 0.0346 | SDpool = 0.2130 | ||
| t exp = 0.177 | t exp = 1.222 | ||
| t (0.05, 4) = 2.776 | t (0.05, 4) = 2.776 | ||
F exp: experimental variance of the method; F (0.05, 2, 2): F distribution at alpha 0.05 and the respective degrees of freedom of numerator and denominator; Spool: pooled variance; texp: experimental t value, t (0.05, 4): t value at risk of 0.05 and 4 degrees of freedom.