TABLE 2.

Overview of QTLs and suggested candidate genes for N-traits identified by GWAS.

Trait	BTAa	QTL interval (Mb)b	Significant SNP	–log10 (P-value)	MAFc	R^2d	Candidate genee
MU	9	29.29–30.29	rs41609177	4.73	0.26	0.06	GJA1, TBC1D32
MU	12	28.84–29.89	rs110792428	4.50	0.42	0.06	RXFP2, FRY
			rs110799535	4.86	0.41	0.06
MUY	17	6.12–7.15	rs41835093	4.81	0.31	0.07	SH3D19, PRSS48, LRBA, RPS3A
			rs41835125	4.36	0.38	0.06
UU	23	18.49–19.49	rs109244808	4.54	0.14	0.05	CLIC5, RCAN2, ENPP4, ENPP5
MN	4	20.65–21.65	rs43375405	4.91	0.44	0.05
MN	16	57.55–58.85	rs41814676	4.52	0.10	0.04	ASTN1
			rs41814682	4.52	0.10	0.04	PAPPA2
MN	17	18.57–19.57	rs41576712	5.89	0.188	0.06	SLC7A11
MN	17	17.56–18.56	rs109749663	4.85	0.06	0.05	MGST2, ELF2
UA	7	63.30–64.30	rs42372803	5.45	0.36	0.06	NMUR2
HA	7	38.87–39.87	rs109848970	8.82	0.07	0.09
HA	12	74.36–75.36	rs43706910	5.96	0.32	0.05
HA	17	69.78–70.78	rs41634411	5.59	0.37	0.06	SFI1
CR	4	116.16–117.16	rs109873598	4.37	0.24	0.05	DPP6
CR	5	82.0–83.00	rs110770413	4.85	0.31	0.06	ARNTL2, ITPR2
CR	5	65.16–66.16	rs41590238	4.83	0.06	0.06	MYBPC1
CR	6	46.21–47.21	rs43705592	4.31	0.32	0.06	STIM2
CR	7	63.44–64.44	rs110536156	5.12	0.40	0.06
CR	7	67.16–68.16	rs42332347	4.53	0.39	0.05	SGCD
CR	18	23.62–24.62	rs109756131	4.74	0.41	0.06	SLC6A2
CRE	16	2.51–3.51	rs41787830	4.35	0.15	0.06	TMCC2, MFSD4A

^aBos taurus autosome.

^bCompiled according to Saatchi et al. (2014).

^cMinor allele frequency of the significant SNP.

^dCalculated by linear regression between phenotype residuals and SNP-alleles.

^eSelected due to a positional or functional association to the trait; MU, milk urea concentration; MUY, milk urea yield; UU, urinary urea; MN, minor N-fractions (non-protein, non-urea) in milk; UA, uric acid; HA, hippuric acid; C, creatine; CRE, creatinine.