Table 1.
Experimental Runs, Independent Variables, and Measured Responses of the 31×41 Full Factorial Experimental Design of Epl-loaded MNLCs
| F (Sorted by Standard Order) | Type of Surface Modifier | Concentration of Surface Modifier (% w:v) | Y1: PS (nm) | Y2: PDI | Y3: ZP (mV) | Y4: EE% (% w:w) | Y5: Viscosity (cP) at Shear Rate (20 [1/s]) |
|---|---|---|---|---|---|---|---|
| MNLC-1 | Hydrogenated collagen | 0.3 | 152.75±15.20 | 0.333±0.01 | −28.1±0.42 | 62.945±1.10 | 39.24±0.1 |
| MNLC-2 | COSL | 0.3 | 282.25±32.31 | 0.382±0.01 | +15.8±0.85 | 69.948±0.77 | 0±0 |
| MNLC-3 | Hyaluronic acid | 0.3 | 167±42.57 | 0.416±0.16 | −44.25±1.63 | 81.285±1.63 | 186.39±0.32 |
| MNLC-4 | Hydrogenated collagen | 0.5 | 155.6±4.10 | 0.362±0.07 | −24.1±0.57 | 63.865±1.89 | 39.24±0.56 |
| MNLC-5 | COSL | 0.5 | 236.15±26.38 | 0.428±0.06 | +20.65±0.49 | 70.583±9.08 | 78.48±0.98 |
| MNLC-6 | Hyaluronic acid | 0.5 | 262.75±84.07 | 0.449±0.03 | −48.1±1.13 | 79.025±1.05 | 333.54±0.15 |
| MNLC-7 | Hydrogenated collagen | 0.7 | 127.773±9.15 | 0.381±0.13 | −27.95±0.21 | 67.281±8.39 | 49.05±0.17 |
| MNLC-8 | COSL | 0.7 | 222.95±11.10 | 0.433±0.03 | +29.3±0.28 | 70.26±0.08 | 29.43±2.11 |
| MNLC-9 | Hyaluronic acid | 0.7 | 261.75±66.40 | 0.434±0.04 | −53.2±1.13 | 88.445±2.80 | 824.04±1.65 |
| MNLC-10 | Hydrogenated collagen | 0.9 | 161.2±5.23 | 0.393±0.04 | −30.944±0.93 | 76.905±7.96 | 39.24±1.24 |
| MNLC-11 | COSL | 0.9 | 397.1±158.11 | 0.428±0.16 | +46.35±1.77 | 74.357±6.73 | 9.81±0.98 |
| MNLC-12 | Hyaluronic acid | 0.9 | 277.45±36.56 | 0.475±0.01 | −54.4±0.49 | 90.775±3.57 | 1373.4±0.47 |
Notes: Data presented as means ± SD (n=3). All systems contained 1.25 mg Epl/1 mL.
Abbreviations: PS, particle size; PDI, polydispersity index; ZP, ζ-potential; EE, entrapment efficiency.