Fig. 2.

Mitochondrial energetics disrupted in PLWH. (a): Oxygen consumption rates (OCR) were recorded using Seahorse XF96 Analyzer during serial injections of electron transport chain inhibitors (i.e., oligo, rot/AA) and a mitochondrial oxidative phosphorylation uncoupler (i.e., FCCP) to quantify mitochondrial respiration. (b): Measures of mitochondrial function in response to mitochondrial stress tests included basal respiration (basal), ATP-linked respiration (ATP; i.e., basal respiration—proton leak), proton leak (proton), maximal respiration (maximal), spare respiratory capacity (SRC; i.e., maximal respiration—basal respiration), and non-mitochondrial respiration (non-Mt) for uninfected controls (shown in blue) and PLWH (shown in red). Y-axes are fixed for both graphs. N = 80, ^#p < .01, *p < .05.