Fig. 5.

DFS curves for TNBC cases using dichotomous models for stromal TILs. Kaplan–Meier curves of the DFS of TNBC patients in the TIL-Low and TIL-High groups based on dichotomization using mTIL-1 (a, f), mTIL-2 (b, g), mTIL-3 (c, h), mTIL-con (d, i), and aTIL models (e, j). The groups were established on the basis of the optimal cutoff stromal TIL scores for DFS using X-Tile. Details on the cutoff points used in the mTIL and aTIL models are demonstrated in Supplementary Figure 2 and Supplementary Figure 3. In the mTILs-con model, a consensus group was generated from individual dichotomized mTIL scores grouped by three pathologists based on the majority voting rule. The cut-off values used were 15%, 9%, 10% and 14.1% for mTILs-1, mTILs-2, mTILs-3 and aTILs in SYSUCC cohort and 15%, 20%, 20% and 12.3% for mTILs-1, mTILs-2, mTILs-3 and aTILs in TCGA cohort. P-value was calculated using log rank test.