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. 2020 Mar 25;34(8):2206–2216. doi: 10.1038/s41375-020-0803-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a SIRT7-expression in AML patients bone marrow depended on treatment response (mean ± SEM; Mann–Whitney rank-sum test (*p < 0.05)). b Clinical cases: SIRT7-expression in bone marrow corresponding to AML-treatment events in case of FLT3-wt and FLT3-ITD-positive AML is shown. c SIRT7-expression was significantly decreased in bone marrow leukocytes of female FLT3-ITD-positive AML patients at first diagnosis compared with wild-type patients (mean ± SEM; Mann–Whitney rank-sum test (*p < 0.05)). d–f MV4-11 (FLT3-ITD-positive) and THP-1 cells (FLT3-wt) (time course), or 32D FLT3-wt- and FLT3-ITD-cells (time course), or Ba/F3 cells (FLT3-wt or different FLT3-ITDs) (24 h) were treated by AC220. FLT3-ITD inhibition resulted in increase of SIRT7-expression (mean ± SEM; value normalization to 0 h sample (d, e) or DMSO control (f); n = 3; significant differences corresponding to 0 h (d, e), FLT3-wt (f) (*p < 0.05) or between FLT3-wt vs. ITD (d, e) (^#p < 0.05) were identified with Student’s t test).