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. 2020 Jul 20;35(3):809–822. doi: 10.1038/s41375-020-0976-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Forest plots on specific subgroups defined by baseline disease characteristics for a PFS and b OS from randomization. Age groups are defined as: ≤60 years (S1), 61–65 years (S2) and 66–70 years (S3). Renal insufficiency is defined as serum creatinine value of >177 μmol/l. Adverse cytogenetics were defined as at least one of the following aberrations: deletion17p13, translocation t(4;14), translocation t(14;16), gain 1q21 (>3 copies). PFS, progression-free survival; OS, overall survival; LDH, lactate dehydrogenase; ULN, upper limit of the normal; WHO, World Health Organization; IA p, interaction test p value.