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. 2021 Jun 23;6(8):1094–1101. doi: 10.1038/s41564-021-00933-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — The encoded ORF9 protein from all Ugandan A.23 and A.23.1 genomes gather, aligned and compared to the ORF9 protein from GenBank NC_045512.2. Panel a: The locations of important ORF9 protein features are indicated based on the analysis of ORF9 from Chang et al.⁶. N-term: amino-terminal extension, NTD: amino-terminal domain, linker: linker region between the NTD and CTD, CTD: carboxy-terminal domain, C-tail: carboxy-terminal extension, Regions with ‘Basic’ indicate the 4 regions enriched in positively charged amino acids. Panel b: Each line represents the encoded ORF9 protein sequence from a single genome, ordered by date of samples collection (bottom earliest, top most recent). Coloured markers indicate the positions of amino acid (aa) substitutions from the reference strain sequence, only substitutions observed in multiple genomes are annotated with the annotation (original aa position new aa) and the labels were placed as close as possible to the substitution.

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