Table 2.

Multivariable Cox-regression to predict all-cause mortality excluding biomarkers

	Overall survival					Survival free of HF hospitalization
	HR	95% CI		Wald	p	HR	95% CI		Wald	p
A: No co-morbidities and age < 75 years
BMI categories				3.4	0.39				2.4	0.49
≤ 18.5 kg/m2	0.954	0.232	3.922	0.0	0.95	0.883	0.325	2.398	0.1	0.81
18.5–25.0 kg/m2	1.140	0.815	1.595	0.6	0.45	1.060	0.840	1.337	0.2	0.63
25.0–30.0 kg/m2	0.887	0.638	1.232	0.5	0.47	0.917	0.732	1.147	0.6	0.45
> 30.0 kg/m2	1				Ref	1				Ref
Age	–	–	–	–	–	1.010	1.001	1.019	5.1	0.02
eGFR	0.985	0.976	0.995	8.8	0.003	–	–	–	–	–
Ischaemic aetiology	1.562	1.219	2.002	12.1	< 0.001	1.267	1.069	1.501	7.4	0.004
NYHA III/IV	1.715	1.335	2.203	18.5	< 0.001	1.564	1.311	1.867	24.6	< 0.001
LVEF	0.960	0.944	0.976	25.0	< 0.001	0.975	0.965	0.986	20.0	< 0.001
Atrial fibrillation	–	–	–	–	–	1.389	1.104	1.748	7.9	0.005
B: At least one co-morbidity or age > 75 years
BMI categories				22.4	< 0.001				10.3	0.02
≤ 18.5 kg/m2	2.037	1.366	3.039	12.2	< 0.001	1.320	0.927	1.880	2.4	0.12
18.5–25.0 kg/m2	1.214	1.009	1.461	4.2	0.04	1.115	0.969	1.285	2.3	0.13
25.0–30.0 kg/m2	0.963	0.802	1.156	0.2	0.69	0.951	0.829	1.090	0.5	0.47
> 30.0 kg/m2	1				Ref	1				Ref
Haemoglobin	0.911	0.874	0.949	20.1	< 0.001	0.911	0.882	0.941	31.9	< 0.001
Age	1.021	1.014	1.028	31.4	< 0.001	1.012	1.007	1.018	18.7	< 0.001
Cancer	1.223	1.016	1.473	4.5	0.03	–	–	–	–	–
COPD	1.266	1.098	1.459	10.6	0.001	1.374	1.228	1.538	30.8	< 0.001
eGFR	0.987	0.983	0.991	39.4	< 0.001	0.990	0.987	0.994	36.9	< 0.001
Ischaemic aetiology	1.232	1.080	1.406	9.6	0.002	1.158	1.045	1.283	7.9	0.005
Diabetes	1.194	1.050	1.357	7.3	0.007	1.318	1.192	1.457	29.1	< 0.001
Female gender	0.652	0.556	0.766	27.3	< 0.001	0.788	0.697	0.891	14.6	< 0.001
NYHA III/IV	1.527	1.347	1.731	43.7	< 0.001	1.340	1.215	1.478	34.4	< 0.001
Atrial fibrillation	1.206	1.035	1.404	5.8	0.02	1.250	1.106	1.413	12.7	< 0.001
LVEF	0.984	0.978	0.991	20.4	< 0.001	0.995	0.990	1.000	3.5	0.06

Abbreviations, see Table 1