Table 2.
Multivariable models for sudden death in I-Preserve
| Sudden death Model 1 | Sudden death Model 2 | |||||||
|---|---|---|---|---|---|---|---|---|
| Number of patients (number of events) | 4109 (230) | 4109 (230) | ||||||
| C statistic | 0.71 (95% CI 0.68–0.75) | 0.72 (95% CI: 0.69–0.75) | ||||||
| Coefficient | sHR (95% CI) | χ2 | p value | Coefficient | sHR (95% CI) | χ2 | p value | |
| Age 60 years or above, per 1 year increase | 0.049 | 1.05 (1.03–1.07) | 25.5 | < 0.001 | 0.05 | 1.05 (1.03–1.07) | 24.8 | < 0.001 |
| Male sex | 0.553 | 1.74 (1.33–2.27) | 16.6 | < 0.001 | 0.551 | 1.74 (1.33–2.27) | 16.3 | < 0.001 |
| LVEF 45–60%, per 1% decrease | 0.053 | 1.05 (1.03–1.08) | 15.7 | < 0.001 | 0.051 | 1.05 (1.02–1.08) | 14.3 | < 0.001 |
| Heart rate 50–100 beats/min, per 5 beats/min | 0.070 | 1.07 (1.01–1.14) | 5.2 | 0.022 | 0.067 | 1.07 (1.01–1.13) | 4.8 | 0.029 |
| History of diabetes | 0.519 | 1.68 (1.28–2.20) | 14.3 | < 0.001 | 0.531 | 1.70 (1.30–2.23) | 14.7 | < 0.001 |
| History of myocardial infarction | 0.419 | 1.52 (1.14–2.02) | 8.3 | 0.004 | 0.435 | 1.54 (1.16–2.05) | 9.0 | 0.003 |
| HF hospitalization within previous 6 months | 0.364 | 1.44 (1.10–1.88) | 7.1 | 0.007 | 0.373 | 1.45 (1.11–1.89) | 7.5 | 0.006 |
| Bundle branch block on ECG | 0.327 | 1.39 (1.00–1.92) | 3.9 | 0.049 | ||||
| Left ventricular hypertrophy on ECG | 0.376 | 1.46 (1.11–1.92) | 7.3 | 0.007 | ||||
| Sudden death Model 3 | Sudden death Model 4 | |||||||
|---|---|---|---|---|---|---|---|---|
| Number of patients (number of events) | 4021 (228) | 3467 (195) | ||||||
| C statistic | 0.71 (95% CI: 0.68–0.75) | 0.75 (95% CI: 0.72–0.78) | ||||||
| Coefficient | sHR (95% CI) | χ2 | p value | Coefficient | sHR (95% CI) | χ2 | p value | |
| Age 60 years or above, per 1 year increase | 0.046 | 1.05 (1.03–1.07) | 21.0 | < 0.001 | 0.034 | 1.03 (1.01–1.06) | 9.5 | 0.002 |
| Male sex | 0.529 | 1.70 (1.30–2.22) | 14.8 | < 0.001 | 0.506 | 1.66 (1.23–2.23) | 11.3 | 0.001 |
| LVEF 45–60%, per 1% decrease | 0.055 | 1.06 (1.03–1.08) | 16.7 | < 0.001 | 0.036 | 1.04 (1.01–1.07) | 5.8 | 0.017 |
| Heart rate 50–100 beats/min, per 5 beats/min | ||||||||
| History of diabetes | 0.547 | 1.73 (1.32–2.27) | 15.5 | < 0.001 | 0.568 | 1.76 (1.31–2.37) | 14.2 | < 0.001 |
| History of myocardial infarction | 0.415 | 1.51 (1.14–2.01) | 8.2 | 0.004 | 0.463 | 1.59 (1.17–2.15) | 9.0 | 0.003 |
| HF hospitalization within the last 6 months | 0.336 | 1.40 (1.07–1.83) | 6.0 | 0.014 | ||||
| Bundle branch block on ECG | ||||||||
| Left ventricular hypertrophy on ECG | 0.395 | 1.48 (1.13–1.95) | 8.0 | 0.005 | 0.34 | 1.40 (1.04–1.90) | 4.9 | 0.027 |
| Albumin 35–45 g/l, per 1 g/l decrease | 0.065 | 1.07 (1.01–1.12) | 6.2 | 0.013 | ||||
| NT-proBNP up to 3000 pg/ml, per 100 pg/ml | 0.048 | 1.05 (1.03–1.06) | 42.6 | < 0.001 | ||||
sHR subdistribution hazard ratio, CI confidence interval, LVEF left-ventricular ejection fraction, ECG electrocardiography, NT-proBNP N-terminal pro-B-type natriuretic peptide
χ2 score: the larger χ2 value, the more powerful the predictor