Fig. 2.

The interactions between Nf2/merlin and LATS1. Center, surface representation of Nf2/merlin (red, oxygen; blue, nitrogen; white, carbon; yellow, sulfur) with LATS1 shown in stick representation. Zoomed-in views of LATS1 (A) at the N-terminal region wherein Phe-71 engages the hydrophobic groove of Nf2/merlin (residues Ala-137, Pro-134, Leu-140, Ile-210, and Leu-214) through hydrophobic interactions, (B) residue Arg-82 engaging in electrostatic interactions with Nf2/merlin residue Glu-136, and (C) residue Phe-88 that stabilizes the exposed hydrophobic surface (Nf2/merlin residues Met-179, Met-183, and Arg-187) via hydrophobic interactions. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)