. 2021 Jun 19;297(2):100906. doi: 10.1016/j.jbc.2021.100906

Table 2.

O-Ac-Sia utilization by human viruses

Virus family	Virus genus	O-Ac-Sia binding	SIAE/GBP	References
Orthomyxoviridae	Influenza C virus (ICV)	Neu5,9Ac₂ (α2-8-linked, GL)	HEF	(218, 222, 223)
Orthomyxoviridae	Influenza D virus (IDV)	Neu5,9Ac₂	HEF	(219, 221, 223)
Coronaviridae	Coronavirus OC43	Neu5,9Ac₂ (α2-8-linked)	HE/S	(223, 230, 232)
Coronaviridae	Coronavirus HKU1	Neu5,9Ac₂ (α2-8-linked)	HE/S	(223, 227, 230, 231, 252)

Specificity for O-Ac-Sias and viral surface proteins involved in binding and hydrolysis of O-Ac-Sias are listed.

Abbreviations: GL, glycolipids; HE, hemagglutinin esterase; HEF, hemagglutinin-esterase fusion protein; S, virus spike protein.