Table 2.

Correlations between burden of illness measures and total episodes and depressive polarity (lifetime).

Measures	Total Episodes (Lifetime)		Depressive Predominant Polarity (Lifetime)
	Mean [95% CI]	p	Mean [95% CI]	p
Years ill	1.66 [1.11, 2.21]	<0.001	0.01 [−0.00, 0.02]	0.051
Gender (F)	−3.24 [−17.63, 11.15]	0.658	0.05 [−0.16, 0.25]	0.662
Employment status	−5.58 [−19.83, 8.66]	0.442	−0.13 [−0.34, 0.07]	0.193
Age of first hypo/manic episode	−2.17 [−2.89, −1.45]	<0.001	0.01 [−0.00, 0.02]	0.194
Age of first depressive episode	−2.17 [−3.04, −1.30]	<0.001	−0.01 [−0.02, 0.00]	0.061
Married (vs not)	9.37 [−6.02, 24.76]	0.232	0.22 [0.00, 0.44]	0.048
Child abuse (vs not)	15.20 [1.02, 29.37]	0.036	0.01 [−0.19, 0.21]	0.926
Primary diagnosis (Bipolar I vs. II)	9.48 [−5.70, 24.66]	0.220	−0.02 [−0.24, 0.19]	0.833
History of suicide attempts	1.75 [−12.46, 15.97]a,b,c	0.809	0.09 [−0.12, 0.30]	0.418
Substance use disorder (lifetime)	4.86 [−8.97, 18.69]a,b,c	0.490	0.02 [−0.19, 0.23]	0.850
Current mood stated
Hypo/manic episode	19.61 [−3.12, 42.34]	0.091	−0.33 [−0.65, −0.00]	0.048
Mixed episode	15.24 [−4.35, 34.83]	0.127	−0.12 [−0.39, 0.16]	0.415
Not meeting full criteria for either	0.78 [−19.55, 21.10]	0.940	0.05 [−0.24, 0.33]	0.757
Type of first episoded
Hypo/manic	30.07 [9.93, 50.21]	0.004	−0.45 [−0.73, −0.16]	0.002
Same age of onset for hypo/manic and depressive episodes	17.69 [0.85, 34.54]	0.040	−0.24 [−0.48, −0.00]	0.049
Any anxiety disorder (lifetime)	8.16 [−5.53, 21.85]a,b,c	0.242	0.23 [0.02, 0.43]	0.030
LIFE-RIFT	0.77 [−1.22, 2.76]a,b,c	0.448	0.00 [−0.03, 0.03]	0.811
Q-LES-Q	−0.13 [−0.52, 0.25]a,b,c	0.498	−0.00 [−0.01, 0.00]	0.103
Percent depressed in previous year	0.80 [−5.00, 6.59]a,b,c	0.787	0.10 [0.02, 0.19]	0.017
Percent hypo/manic in previous year	15.32 [8.77, 21.86]a,b,c	<0.001	−0.33 [−0.42, −0.23]	<0.001
Number of antidepressant medications (lifetime)	1.34 [−1.65, 4.34]a,b,c	0.378	0.07 [0.02, 0.11]	0.003
Number of antimanic medications (lifetime)	3.20 [−0.33, 6.74]a,b,c	0.076	0.05 [−0.01, 0.10]	0.086
Number of psychotropic medications (lifetime)	−6.32 [−11.42, −1.21]a,b,c	0.016	0.10 [0.03, 0.18]	0.007
Number of psychiatric hospitalizations (lifetime)	0.68 [−0.96, 2.33]a,b,c	0.415	0.00 [−0.02, 0.03]	0.726

Note:

^aAdjusted for years ill,

^bAdjusted for age of first episode,

^cAdjusted for type of first episode;

^dReference category is Depressed mood;

LIFE-RIFT = Longitudinal Interval Follow-up Evaluation-Range of Impaired Functioning Tool; Q-LES-Q = Quality of Life Enjoyment and Satisfaction Questionnaire