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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Cortex. 2021 May 25;141:403–420. doi: 10.1016/j.cortex.2021.04.016

Figure 5:

Figure 5:

Model 3. Model 3 builds upon model 2 by adding within-tract white matter hyperintensity burden as a latent variable that directly influences white matter fractional anisotropy. This allows examination of the detrimental effects of lesion-like infarcts within white matter tracts of interest, and their overall influence on cognitive abilities. Years of education and sex were regressed from all latent variables modeled. Intracranial volume was regressed from white matter hyperintensity burden. Note: EF = executive function; CWI = color word interference; PS = processing speed; WMFA = white matter fractional anisotropy; FA = fractional anisotropy; IFOF = inferior frontal occipital fasciculus; SLF = superior longitudinal fasciculus; WMH = white matter hyperintensity burden; EDU = years of education; ICV = intracranial volume.