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. Author manuscript; available in PMC: 2022 Jul 26.
Published in final edited form as: Dev Cell. 2021 Jul 8;56(14):2089–2102.e11. doi: 10.1016/j.devcel.2021.06.013

Figure 3. p53 loss rescues Rps6 haploinsufficiency phenotypes, and p53 activation mediates translational changes upon Rps6 reduction.

Figure 3.

(A-D) E17.5 forelimbs of WT and Prx1Cre;Rps6lox/+ embryos in Trp53 WT (Trp53+/+) and Trp53 null (Trp53−/−) backgrounds. Arrow indicates absence of radius. Scale bars, 1 mm.

(E) Potential pathways for p53-dependent translational control upon Rps6 haploinsufficiency.

(F) OPP MFI of cells dissociated from whole E10.5 forelimbs normalized to WT (Rps6lox/+). n = 5 embryos.

(G) HPG MFI of mouse embryonic fibroblasts treated with Nutlin-3a or Doxo normalized to DMSO treated control. 8 h treatment, n = 4.