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. 2021 Jul 28;12(8):747. doi: 10.1038/s41419-021-04024-9

Fig. 3. Effect of exosomal miR-1260b on cisplatin-induced apoptosis.

Fig. 3

A A549, B PC-9, and D Calu-1 cells were transfected with 50 nM control miRNA (CT), miR-1260b mimic, or anti-miR-1260b mimic for 24 h and then treated with 10 μM cisplatin for 48 h. Apoptosis was measured by flow cytometry. C Cleaved PARP and caspase-3 were detected by western blotting. E PC-9 cells were treated with 50 μg exosomes from A549, miR-1260b-overexpressing A549, or anti-miR-1260b-overexpressing A549 cells and treated with the indicated doses of cisplatin for 48 h. Apoptosis was measured by flow cytometry. F Cleaved PARP and caspase-3 were detected by western blotting. The results are reported as the mean ± standard deviation of three independent experiments. *P < 0.05, **P < 0.005, ***P < 0.0005 compared with the control group.