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. 2021 Jul 28;12(8):748. doi: 10.1038/s41419-021-04033-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a miR-526b-3p and STAT3 expression is accessed by qRT-PCR. b The activity of MDR1 is measured by rhodamine123 efflux assay. RLU relative fluorescence of unit. c The viability of the indicated cells is accessed by MTT assay. d The expression of the indicated genes is detected by qRT-PCR and Western blot, separately. e Representative immunofluorescent images of STAT3 and PD-L1 in A549 cells are shown. f The percentage of CD8 positive T-cells in the indicated cells are accessed by flow cytometry analysis. g The motility of the indicated cells was detected by transwell migration assay. Scale bar, 100 µm. *, P < 0.05 vs control. #, P < 0.05 vs miR-526b-3p plus vector.