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. 2021 Jul 28;4:920. doi: 10.1038/s42003-021-02428-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A computer model was developed to simulate delivery kinetics of IV-DDS. The model was validated by quantitative intravital microscopy studies where fluorescent dye encapsulated in thermosensitive liposomes (TSL) served as example IV-DDS. The computer model was based on in vitro measured IV-DDS (i.e., TSL) release kinetics, and on in vivo measured parameters from the in vivo studies with free dye (parameters marked by asterisks (*), see Fig. 6). The computer model predicted intra- and interstitial/EES concentrations during IV-DDS delivery, which were validated against results from the intravital studies (right-side graphs).