Table 1.
In vivo measured tumor transport parameters and pharmacokinetic parameters.
| Parameter | Value | Parameter description | Source |
|---|---|---|---|
| Tumor transport parameters | |||
| vp | 0.23 ± 0.07 | Tumor plasma volume fraction (plasma represents 23% of tumor tissue) | Intravital Imaging |
| ve,av | 0.28 ± 0.13 | Available extravascular tumor volume fraction (28% of extravascular volume is available to dye for distribution) | Intravital Imaging |
| TT | 5.0 ± 0.5 s | Tissue transit time of tumor segment (time that plasma requires to pass through the imaged tumor segment) | Intravital Imaging |
| PS# | 0.012 ± 0.005 s−1 | Vascular permeability-surface area product (determines how fast dye transport between plasma and extravascular space occurs) | Intravital Imaging |
| Fp | 0.047 ± 0.02 mL/(mL s) | Tumor plasma perfusion rate | Calculated from vp, TT |
| EF# | 0.22 | First-pass extraction fraction (22% of dye is extracted by tissue during first pass) | Calculated from PS, Fp |
| Pharmacokinetic parameters | |||
| VD# | 8.99 ± 0.58 mL | Initial volume of distribution (Peak plasma concentration = (Injected dose)/VD) | Serial blood sampling |
| kp# | 1.29 ± 0.52 × 10−3 s−1 | Transport rate constant, tissue → plasma | Serial blood sampling |
| kt# | 0.90 ± 0.22 × 10−3 s−1 | Transport rate constant, plasma → tissue | Serial blood sampling |
| ke# | 0.80 ± 0.30 × 10−3 s−1 | Elimination rate constant | Serial blood sampling |
Tumor transport parameters were measured from intravital imaging studies, and pharmacokinetic parameters are based on additional serial blood sampling studies (Fig. 6). The tumor transport parameters are specific to the tumor segment visible under imaging and may not be representative of the whole tumor.
The table is separated into two sections identified by the labels “Tumor transport parameters” and “Pharmacokinetic parameters”. Column headings are identified in bold font.
#Parameters are specific to the employed drug/dye, here carboxyfluorescein (CF).