Table 2.
In vivo values for key indices.
| Parameter | Value | Parameter description | Source |
|---|---|---|---|
| P.I. (=PS/Fp) | 0.26 | Permeability Index (=Ratio vascular permeability-surface area product/ tumor plasma perfusion) | Calculated from parameters PS, Fp (Table 1) |
| EF | 0.22 | First-pass extraction fraction (Unencapsulated drug) | Calculated from parameters PS, Fp (Table 1) |
| TT | 5.0 ± 0.5 s | Tissue transit time of tumor segment | Intravital Imaging (Table 1) |
| trel_fTSL | 8.2 s | fTSL release time | In vitro essay |
| trel_sTSL | 63.0 s | sTSL release time | In vitro essay |
| R.I.fTSL (=trel_fTSL/TT) | 1.6 | Release Index for fTSL (=Ratio fTSL release time / tissue transit time) | Calculated |
| R.I.sTSL (=trel_sTSL/TT) | 12.6 | Release Index for sTSL (=Ratio sTSL release time / tissue transit time) | Calculated |
The permeability index P.I.(=PS/Fp) and release index R.I.(=trel/TT) was calculated from experimental data, and experimental values of the two indices are indicated in Fig. 5a as dotted lines.
Column headings are identified in bold font, parameters are identified in italic font.