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. 2021 Jul 28;11:15313. doi: 10.1038/s41598-021-94500-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially expressed genes in P19 OIR + AFL(× 3) relative to P19 OIR + AFL(× 2) retinas, GO terms enriched among them, and comparison with differentially regulated genes throughout murine retinal development. (a,b) Expression levels of genes differentially up-regulated (a) and down-regulated (b) in P19 OIR + AFL(× 3) relative to P19 OIR + AFL(× 2) retinas. Expression is shown for P19 OIR, OIR + AFL(× 2) and OIR + AFL(× 3) retinas normalized to the expression level detected in normoxic age-matched tissues. (c) GO terms enriched in the list of differentially expressed genes in P19 OIR + AFL(× 3) retinas relative to P19 OIR + AFL(× 2) retinas. Domains: biological process, top; molecular function, middle; cellular component, bottom. (d) Venn diagrams of differentially up-regulated (left) and down-regulated (right) genes in P19 OIR + AFL(× 3) retinas relative to P19 OIR + AFL(× 2) ones and during normal retinal development in the P14 to P17 period (top) or in the P17 to P19 timeframe (bottom). In (a,b) error bars depict + 1 S.E.M. and statistical significance was calculated relative to expression levels in age-matched normoxic retinas. *P < 0.05; **P < 0.01; ***P < 0.001.