Table 3.
Association* of Carotenoids and Retinol with Extent of Prostate Biopsy Cores Inflamed in 235 Men without Prostate Cancer and Irrespective of Indication for Biopsy**, Placebo Arm, PCPT
Extent of Biopsy Cores Inflamed | ||||||||
---|---|---|---|---|---|---|---|---|
None | Any | Some | All | |||||
Tertile*** | N | N | OR (95%CI) | N | OR (95%CI) | N | OR (95%CI) | |
β-cryptoxanthin | 1 | 25 | 53 | 1.00 | 33 | 1.00 | 20 | 1.00 |
2 | 12 | 67 | 2.67 (1.19,5.99) | 46 | 2.98 (1.27,6.97) | 21 | 2.16 (0.83,5.63) | |
3 | 16 | 62 | 1.80 (0.84,3.82) | 43 | 2.03 (0.91,4.53) | 19 | 1.40 (0.55,3.53) | |
Lycopene | 1 | 16 | 62 | 1.00 | 42 | 1.00 | 20 | 1.00 |
2 | 22 | 57 | 0.56 (0.26,1.21) | 38 | 0.57 (0.26,1.28) | 19 | 0.54 (0.21,1.38) | |
3 | 15 | 63 | 1.38 (0.59,3.25) | 42 | 1.33 (0.55,3.23) | 21 | 1.51(0.56,4.08) | |
α-carotene | 1 | 19 | 59 | 1.00 | 37 | 1.00 | 22 | 1.00 |
2 | 16 | 63 | 1.30 (0.60,2.79) | 43 | 1.39 (0.63,3.12) | 20 | 1.13 (0.45,2.83) | |
3 | 18 | 60 | 1.02 (0.49,2.22) | 42 | 1.16 (0.52,2.58) | 18 | 0.82 (0.33,2.07) | |
β-carotene | 1 | 16 | 62 | 1.00 | 41 | 1.00 | 21 | 1.00 |
2 | 19 | 60 | 0.73 (0.33,1.58) | 41 | 0.76 (0.34,1.72) | 19 | 0.65 (0.26,1.66) | |
3 | 18 | 60 | 0.81 (0.37,1.79) | 40 | 0.83 (0.36,1.89) | 20 | 0.79 (0.31,2.03) | |
Sum of these carotenoids | 1 | 22 | 56 | 1.00 | 38 | 1.00 | 18 | 1.00 |
2 | 13 | 66 | 1.35 (0.63,2.90) | 43 | 1.34 (0.60,2.99) | 23 | 1.38 (0.55,2.99) | |
3 | 18 | 60 | 1.33 (0.61,2.90) | 41 | 1.32 (0.58,3.00) | 19 | 1.35 (0.53,3.49) | |
Retinol | 1 | 17 | 61 | 1.00 | 42 | 1.00 | 19 | 1.00 |
2 | 15 | 64 | 1.31 (0.59,2.89) | 41 | 1.21 (0.53,2.78) | 23 | 1.53 (0.60,3.92) | |
3 | 21 | 57 | 0.78 (0.35,1.65) | 39 | 0.75 (0.33,1.70) | 18 | 0.77 (0.30,1.99) |
Models adjusted for baseline age, cholesterol, race, family history prostate cancer.
92.8% did not have a clinical indication for biopsy
Tertile ranges (nmol/mL): β-cryptoxanthin: T1: 0.0139 to <0.122, T2: 0.122 to <0.203, T3: 0.203 to 0.728; lycopene: T1: 0.0700 to <0.548, T2:0.548–0.782, T3:0.786 to 1.90; α-carotene: T1:0.0169 to <0.0655, T2: 0.0655 to <0.111, T3: 0.111 to 0.894; β-carotene: T1: 0.0437 to <0.326, T2: 0.326 to <0.567, T3: 0.567 to 6.63; sum of these carotenoids: T1: 0.145 to <1.18, T2: 1.18 to <1.67, T3: 1.67–9.31; retinol: T1: 1.36 to <2.15, T2: 2.15 to <2.609, T3: 2.609 to 5.15.