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. 2021 Jul 28;12:4593. doi: 10.1038/s41467-021-24927-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a The BOLD signal in two distinct sub-regions of the ACC covaried trial-to-trial with unrecoverable (UF) and recoverable fatigue (RF) states estimated by the model. Overlay of clusters in the anterior Rostral Cingulate Zone (RCZa; dark blue) with activity covarying with UF, and the posterior Rostral Cingulate Zone (RCZp; cyan) with activity covarying with RF. Inset shows non-overlapping clusters. RCZ regions defined with respect to the parcellation of Neubert et al.⁴³. b Activity in the middle frontal gyri (MFG) covaried with UF. Images displayed at p < 0.001 uncorrected. Parameter estimates (arbitrary units) at peak coordinates from RCZa (c), RCZp (d) and MFG (e) for UF, RF and fatigue-weighted subjective value (SV). Each dot represents one subject. Error bars reflect SEM. All n = 36.