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. 2021 Feb 21;15(8):2233–2247. doi: 10.1038/s41396-021-00919-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Heatmap displays frequency for each mutation (rows) in UE3 (A) and HR2 (B) across 1 K generation, EPDs, and clonal isolates (columns). The upper panel shows genotype map of Dv and the lower panel for Mm. The hierarchical tree indicates a simplified lineage map of mutations in Dv within each evolution line, with SR phenotypes indicated.