Fig. 2.

SCA7 mice spend a greater percentage of time in apnea during a hypercapnic/hypoxic challenge, and breathe more erratically at baseline at 8 weeks of age. (A) During the respiratory challenge at 8 weeks, SCA7 mice spent a greater percentage of time in apnea than wild-type (WT) mice. (B) During baseline breathing, SCA7 mice had an increased coefficient of variation of inspiratory time compared to wild-type mice. (C) A representative tracing of wild-type and SCA7 breathing during a challenge, chosen to represent the apneic episodes in SCA7 mice (indicated by black triangles). (D) A representative tracing of wild-type and SCA7 breathing during baseline chosen to illustrate the variability in inspiratory times in SCA7 mice. Data are mean±s.e.m. Statistical significance was determined using an unpaired two-tailed Student's t-test (**P<0.01, n=10 mice per group).