Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mechanism for the hydrolysis of imipenem by class B1 MBLs and inhibition by aspergillomarasmine A (AMA). Catalysis by binuclear MBLs involves two Zn2+ cofactors bound in the Zn1 and Zn2 sites. E, ES, and P represent the free enzyme, enzyme–substrate complex, and product, respectively. AMA interferes MBL catalysis by removing one of the Zn2+ cofactors. MBL, metallo-β-lactamase.
