Table 2.
Severity of the disease during the first 24 hours of ICU/ICW admission
| Variable | All participants n = 320 |
Survivors n = 257 |
Non-survivors n = 63 |
|---|---|---|---|
| Acute organ failure | |||
| Respiratory failure | |||
| RR > 30/min or mechanical ventilation, n (%) | 211 (65.9) | 165 (64.0) | 46 (73.8) |
| PaO2/FiO2 ratio (mmHg), median [IQR] | 187 [90–336] | 200 [98–350] | 142 [73–260] |
| ARDS, n (%) | 120 (37.7) | 82 (32.0) | 38 (61.0) |
| Shock | |||
| SBP < 90, DBP < 60 or vasopressors, n (%) | 116 (36.2) | 81 (31.3) | 35 (56.0) |
| Renal failure | |||
| Renal replacement therapy, n (%) | 22 (6.9) | 12 (4.7) | 10 (15.9) |
| Altered mental status (CGS < 14), n (%) | 83 (28.2) | 66 (27.8) | 17 (29.8) |
| Severity scores | |||
| SAPS II (points), median [IQR] | 37 [28–55] | 34 [26–48] | 59 [40–81] |
| SOFA (points), median [IQR] | 5 [2–8] | 4 [2–7] | 8 [4–14] |
| Pneumonia Severity Index, median [IQR] | 129 [100–160] | 122 [96–153] | 152 [131–186] |
| Risk class, n (%) | |||
| II | 35 (7.9) | 25 (9.7) | 0 (0.0) |
| III | 33 (10.2) | 31 (11.9) | 2 (3.3) |
| IV | 105 (32.8) | 92 (35.7) | 13 (21.4) |
| V | 157 (49.1) | 110 (42.8) | 47 (75.2) |
| CURB65, median [IQR] | 2 [1–3] | 2 [1–3] | 3 [2–4] |
| Risk class, n (%) | |||
| 0 | 24 (7.4) | 21 (8.2) | 3 (4.1) |
| 1 | 67 (21.0) | 58 (22.6) | 9 (14.5) |
| 2 | 83 (26.0) | 72 (28.1) | 11 (17.2) |
| 3 | 86 (26.7) | 69 (26.8) | 17 (26.3) |
| 4 | 41 (12.9) | 26 (10.0) | 15 (15.4) |
| 5 | 19 (6.1) | 11 (4.3) | 8 (8.4) |
Components of the severity scores were imputed when missing: RR > 30/min or mechanical ventilation (n = 6), PaO2/FiO2 ratio (n = 96), ARDS (n = 9), shock (n = 6), altered mental status (n = 26), SAPS II (n = 6). Patient counts for these scores were rounded over the 30 imputed datasets
RR respiratory rate, PaO2 partial pressure of oxygen, FiO2 fraction of inspired oxygen, ARDS acute respiratory distress syndrome, SBP/DBP systolic/diastolic blood pressure, CGS Glasgow coma scale, SAPS simplified acute physiology score, SOFA sequential organ failure assessment