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Target IL1/LIF/JAK/STAT 3 pathway, which could activate iCAFs in pancreas. It may become potentially effective targeted therapies for PDAC. IL-1β, interleukin-1β; IL-1R, interleukin-1 receptor; LIF, leukemia inhibitory factor; JAK, Janus kinase; STAT 3, signal transducer and activator of transcription 3; iCAFs, inflammatory cancer-associated fibroblasts.
