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IL-6 is an important marker of iCAFs; it is worth to explore the effect of IL-6 inhibition or its receptor on PDAC progression. IL-6, interleukin-6; PDAC, pancreatic ductal adenocarcinoma; MAPK, mitogen-activated protein kinase; NK cell, natural killer cell; STAT 3, signal transducer and activator of transcription 3; SAA, serum amyloid A.
