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. 2021 Jul 15;15:699315. doi: 10.3389/fncel.2021.699315

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Copyright © 2021 Chai, Chen, Xu, Zhang, Li, Li, Zhang, Zhang, Zhang, Mao, Ding, Xu and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The field excitatory postsynaptic potentials (fEPSP) recordings in CA1 region of PTEN CKO mice in brain slices. (A) The input-output curve in CA1 by stimulating Schaffer-collaterals was not significant difference between PTEN CKO and WT mice (n = 12 from 5 mice for WT, n = 18 from 7 mice for CKO; Main effect of stimuli, F_(4,112) = 85.57, P < 0.0001; Main effect of group, F_(1,28) = 0.00065, P = 0.9798; Interaction effect of group x stimuli, F_(4,112) = 0.02257, p = 0.9990). (B) Paired-pulse facilitation was significantly enhanced in PTEN CKO mice as compared with WT mice (n = 6 from 3 mice for WT, n = 7 from 3 mice for CKO; Main effect of interval, F_(4,44) = 98.89, P < 0.0001; Main effect of group, F_(1,11) = 18.93, P = 0.0012; Interaction effect of group x interval, F_(4,44) = 2.241, P = 0.0799. Sidak’s post hoc test. P = 0.0159 at 50 ms; P = 0.0074 at 100 ms; P = 0.0019 at 150 ms; P = 0.0507 at 200 ms; P = 0.4654 at 1000 ms). (C) Short-term augmentation at 20 Hz was also significantly enhanced in PTEN CKO mice as compared with WT mice (n = 9 from 3 mice for WT, n = 11 from 4 mice for CKO; Main effect of stimuli, F_(29,522) = 88.3, P < 0.0001; Main effect of group, F_(1,18) = 4.576, P = 0.0464; Interaction effect of group x stimuli, F_(29,522) = 2.524, P < 0.001). (D) Long-term potentiation was not significantly different between PTEN CKO and WT mice (n = 13 from 6 mice for WT, n = 8 from 4 mice for CKO; Last 2 min, t = 1.043, P = 0.3096; P > 0.05). Data presented as mean ± SEM. Statistical analysis was performed by using student’s t test or Two-way ANOVA followed by Sidak’s post hoc analysis.