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. 2021 Jul 15;8:640042. doi: 10.3389/fmolb.2021.640042

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Copyright © 2021 Parzibut, Henket, Moermans, Struman, Louis, Malaise, Louis, Misset, Njock and Guiot.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Canonical pathways associated with exosomal miRNAs altered in the plasma of ARDS patients. (A) Diseases and disorders associated with ARDS-exosomal miRNAs. (B) Disease or function annotation related to inflammatory response associated with ARDS-exosomal miRNAs. (C) Canonical pathways associated with ARDS-exosomal miRNAs. Seven ARDS-related miRNAs that showed robust changes (five upregulated miRNAs: miR-142-5p, miR-122-5p, miR-223-3p, Let-7d-3p, and miR-24-3p, and two downregulated miRNAs: Let-7a-5p and miR-486-5p) were subjected to the IPA tool.