Table 2.
Laboratory findings of patients with MPP on admission.
| Laboratory information | Normal group (n=106) | Mild-moderately elevated group (n=204) | Severely elevated group (n=46) | P-value |
|---|---|---|---|---|
| Routine blood test | ||||
| White blood cell (×109/L) | 7.72 (6.28~9.79) | 7.33 (5.79~9.36) | 8.22 (6.72~10.65) c* | 0.048 |
| Neutrophil, % | 57.7 (43.5~65.2) | 65.4 (55.9~71.8) a# | 75.9 (66.8~81.2) b#,c# | 0.000 |
| Lymphocyte, % | 31.2 (25.9~44.8) | 24.7 (18.9~32.5) a# | 17.2 (12.6~25.7) b#,c# | 0.000 |
| Hemoglobin, g/L | 122 (113~128) | 122 (116~129) | 119 (114~129) | 0.197 |
| Platelet (×109/L) | 336 (267~405) | 288 (222~361) a# | 262 (197~336) b# | 0.000 |
| CRP, mg/L | 3.4 (0.5~12.7) | 15.1 (6.2~37.0) a# | 56.2 (23.4~95.3) b#,c# | 0.000 |
| LDH, IU/L | 334 (272~438) | 440 (348~591) a# | 678(542~944) b#,c# | 0.000 |
| PAB, g/L | 0.11 (0.10~0.14) | 0.10 (0.08~0.13) a# | 0.08 (0.06~0.12) b#,c# | 0.000 |
| Subpopulations of T lymphocytes, % | ||||
| CD3 | 65.55 (58.48~74.84) | 66.68 (59.92~74.23) | 63.55 (54.74~72.39) | 0.156 |
| CD4 | 36.98 (31.64~43.66) | 36.15 (29.90~42.09) | 28.23 (23.76~36.60) b#,c# | 0.000 |
| CD8 | 20.92 (16.70~26.28) | 23.33 (19.44~28.99) a# | 26.48 (22.95~33.09) b#,c# | 0.000 |
| Total Immunoglobulin (Ig) | ||||
| IgG, g/L | 8.80 (7.10~10.73) | 8.95 (7.60~10.70) | 8.35 (7.18~10.63) | 0.475 |
| IgA, g/L | 1.02 (0.69~1.37) | 1.28 (0.87~1.78) a# | 1.25 (0.99~1.64) b# | 0.000 |
| IgM, g/L | 1.57 (1.16~2.03) | 1.65 (1.22~2.24) | 1.55 (0.99~2.40) | 0.229 |
| IgE, IU/ml | 96.9 (37.6~218.5) | 93.9 (38.4~290.5) | 99.9 (51.1~287.3) | 0.855 |
| Cytokines, pg/ml | ||||
| IL-2 | 1.4 (1.1~1.7) | 1.4 (1.1~1.7) | 1.6 (1.1~2.4) | 0.190 |
| IL-4 | 2.0 (1.7~2.3) | 2.0 (1.6~2.5) | 2.2 (1.4~2.8) | 0.593 |
| IL-6 | 16.9 (7.9~43.4) | 26.7 (13.3~57.8) a* | 59.5 (24.2~120.3) b#,c# | 0.000 |
| IL-10 | 5.5 (4.4~7.6) | 8.5 (6.0~12.0) a# | 9.4 (7.1~16.0) b#,c* | 0.000 |
| TNF-α | 2.5(1.8~4.6) | 2.3(1.8~4.1) | 1.7 (1.0~2.6) b#,c# | 0.000 |
| IFN-γ | 3.2 (2.2~4.8) | 5.1 (2.8~10.8) a# | 8.4 (4.0~40.1) b#,c* | 0.000 |
| D-dimer, mg/L | 0.37 (0.25~0.44) | 1.26 (0.82~2.07) a# | 7.68 (6.22~14.16) b#,c# | 0.000 |
Data are presented as the median (25th-75th percentile). *P < 0.05, #P < 0.01; acompared between normal group and mild-moderately elevated group; bcompared between normal group and severe elevated group; ccompared between mild-moderately elevated group and severely elevated group. CRP, C-reactive protein; LDH, Lactate dehydrogenase; PAB, Prealbumin; IL-2, Interleukin 2; IL-4, Interleukin 4; IL-6, Interleukin 6; IL-10, Interleukin 10; TNF-α, Tumor necrosis factor-alpha; IFN-γ, Interferon-gamma.