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. 2021 Jul 15;11:692544. doi: 10.3389/fcimb.2021.692544

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Copyright © 2021 Galaski, Shhadeh, Umaña, Yoo, Arpinati, Isaacson, Berhani, Singer, Slade, Bachrach and Mandelboim

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fnn specifically binds to the N-terminal domain of human CEACAM1. (A) 721.221 cells coated with FITC-labeled Fnn were stained with 2 μg of human CEACAM1-Ig, ∆N CEACAM1-Ig that lacks the N-terminal domain, CEACAM3-Ig, CEA-Ig, CEACAM6-Ig, CEACAM8-Ig, mouse CEACAM1-Ig (mCEACAM1-Ig) or rhesus macaque CEACAM1-Ig (macCEACAM1-Ig). Filled grey histograms represent staining with secondary antibody only. Representative histograms from three independent repeats are shown. (B) CEACAM1-Ig and (C) CEA-Ig staining quantified and shown as fold increase in MFI relative to secondary only. Bars represent means of three independent experiments ± SD. Statistical significance was assessed using a two-tailed unpaired t test. *p ≤ 0.05.