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. 2021 Jul 20;2(3):100641. doi: 10.1016/j.xpro.2021.100641

Figure 10.

Figure 10

The influence of escape of CYBB from XCI and the influence of the SNP rs5964151 in human pDCs on the mRNA expression of CYBB at the single-cell level

(A) Comparison of the mRNA expression of CYBB between female pDCs with monoallelic expression of CYBB (blue circles monoallelic expression of the major allele, orange circles monoallelic expression of the minor allele) to female pDCs with biallelic expression (pDCs with escape from XCI, green circles). Unstimulated pDCs derived from frozen PBMCs of one female are displayed. Each dot represents one single cell. Median (red bar) with interquartile range (black bars) is shown. Mann–Whitney test was used for statistical analysis. ∗∗∗∗p < 0.0001. Expression patterns were determined using the SNP rs5964151 in CYBB.

(B) Comparison of the mRNA expression of CYBB between female pDCs with monoallelic expression of the major allele (blue circles) and monoallelic expression of the minor allele (orange circles). Unstimulated pDCs derived from frozen PBMCs of one female are displayed. Each dot represents one single cell. Median (red bar) with interquartile range (black bars) is shown. Mann–Whitney test was used for statistical analysis. ns = not significant.