REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
CD11c-PE/Cy7 (Bu15)	BioLegend	Cat#: 337216 RRID: AB_2129790
CD123-FITC (6H6)	BioLegend	Cat#: 306014 RRID: AB_2124259
CD14-APC/Cy7 (HCD14)	BioLegend	Cat#: 325620 RRID: AB_830693
CD19-BUV737 (SJ25C1)	BD	Cat#: 564303 RRID: AB_2716867
CD3-BUV737 (UCHT1)	BD	Cat#: 564307 RRID: AB_2744390
CD56-BUV395 (NCAM16.2)	BD	Cat#: 563554 RRID: AB_2687886
HLA-DR-BV605 (L243)	BioLegend	Cat#: 307640  RRID: AB_2561913
Biological samples
Human blood	Healthy individuals from the University Medical Center Hamburg-Eppendorf	Cat#: N/A
Chemicals, peptides, and recombinant proteins
DNA Suspension Buffer, pH 8.0, DNase/RNase Tested, PCR Grade	Teknova	Cat#: T0221
Sso Fast EvaGreen Supermix with Low ROX	Bio-Rad	Cat#: 1725210
Fast Probe Master Mix	Biotium	Cat#: 31005
Aqua ad iniectabilia (DNA-free water)	Braun	Cat#: 235 1744
ACK Lysing Buffer	Lonza	Cat#: 10-548E
Biocoll-Trennlösung	Biochrom	Cat#: L6115
Dulbecco’s Phosphate Buffered Saline (PBS)	Sigma-Aldrich	Cat#: D8537
Dymethyl sulfoxide (DMSO)	Sigma-Aldrich	Cat#: D5879-100ML
Fetal bovine serum (FBS) superior	Biochrom	Cat#: S0615
ROX Reference Dye	Thermo Fisher Scientific	Cat#: 12223012
RPMI-1640 Medium	Life Technologies	Cat#: 21875091
Critical commercial assays
C1 Single-Cell Reagent Kit for Preamp	Fluidigm	Cat#: 100-5319
DNeasy Blood & Tissue Kit (250)	QIAGEN GmbH	Cat#: 69506
GE 96.96 Dynamic Array™ DNA Binding Dye Sample & Assay Loading Reagent Kit with Control Line Fluid	Fluidigm	Cat#: 100-3415
QIAGEN Multiplex PCR Kit	QIAGEN	Cat#: 206143
Plasmacytoid Dendritic Cell Isolation Kit II, human	Miltenyi Biotec	Cat#: 130-097-415
Single Cell-to-CT qRT-PCR Kit	Thermo Fisher Scientific	Cat#: 4458237
SNP Type™ 192.24 Genotyping Reagent Kit with Control Line Fluid	Fluidigm	Cat#: 100-4136
Zombie Aqua™ Fixable Viability Kit	BioLegend	Cat#: 423102
Oligonucleotides
CYBB - pre-amplification – forward primer AAGGAAATTTTCCAGATCATTAGGACA	This paper	N/A
CYBB - pre-amplification – reverse primer CCCAGTTACCCTGCTGTATTAGTA	This paper	N/A
CYBB – quantitative PCR – forward primer GAGAGTGTCTCAACACTTATTAGTGAC	This paper	N/A
CYBB – quantitative PCR – reverse primer CCCAGTTACCCTGCTGTATTAGTA	This paper	N/A
CYBB - SNP typing (rs5964151) - forward primers ACATGTTGAGAGTGTCTCAACACTTAT ACATGTTGAGAGTGTCTCAACACTTAG	This paper	N/A
CYBB - SNP typing (rs5964151) - reverse primer GGAGTATGCTCAGATGTCAATACTGTCA	This paper	N/A
B2M - pre-amplification + quantitative PCR – forward primer TTAGCTGTGCTCGCGCTAC	This paper	N/A
B2M - pre-amplification + quantitative PCR – reverse primer CTCTGCTGGATGACGTGAGTAA	This paper	N/A
IRF2BP2 - pre-amplification + quantitative PCR – forward primer GGCCCTTCGAGAGCAAGTTTAA	This paper	N/A
IRF2BP2 - pre-amplification + quantitative PCR – reverse primer TGGTTCTGGAGAGGGCTTCC	This paper	N/A
TLR7 - pre-amplification – forward primer TGGGCACCACACAGGT	This paper	N/A
TLR7 - pre-amplification – reverse primer CTGTTTCCCTATGGAACCCAGAA	This paper	N/A
TLR7 - quantitative PCR – forward primer ACAGGTGGTTGCTGCTTCA	This paper	N/A
TLR7 - quantitative PCR – reverse primer CTGTTTCCCTATGGAACCCAGAA	This paper	N/A
TLR7 - SNP typing (rs3853839) – forward primers CTTCAGTGCTTCCTGCTCTTTTTC CTTCAGTGCTTCCTGCTCTTTTTG	This paper	N/A
TLR7 - SNP typing (rs3853839) – reverse primer CTATGGAACCCAGAAGCAGGC	This paper	N/A
Software and algorithms
CLC Main Workbench, version 7.9.1	QIAGEN Aarhus A/S	https://digitalinsights.qiagen.com/
FlowJo10	FlowJo LLC	http://www.flowjo.com
Fluidigm Real-Time PCR Analysis, version 4.3.1	Fluidigm	https://www.fluidigm.com/
Fluidigm SNP Genotyping Analysis; version 4.3.2	Fluidigm	https://www.fluidigm.com/
GraphPad Prism 9	GraphPad Software, LLC	https://www.graphpad.com/
Microsoft PowerPoint 2016	Microsoft	https://www.microsoft.com
Other
192.24 Dynamic Array™ IFC for SNP Genotyping	Fluidigm	BMK-M-192.24GT
48.48 Dynamic Array™ IFC for Genotyping	Fluidigm	BMK-M-48.48GT
96.96 Dynamic Array™ IFC for Gene Expression	Fluidigm	BMK-M-96.96
C1™ Single-Cell Preamp IFC, 5–10 μm	Fluidigm	100-5757
qPCR foil	SARSTEDT	95.1994
PCR plate half skirt, 96 well	SARSTEDT	72.1979.102
Sterican single-use cannula, blunt (Ø 0.8 × 22 mm)	Braun	918 0109
8-Channel pipette (0.5 μL–10 μL)	Rainin	17013802
8-Channel pipette (5 μL–50 μL)	Rainin	17013804
C1	Fluidigm	N/A
Biomark HD	Fluidigm	N/A
Juno	Fluidigm	N/A
Fluorescence-activated cell sorter (FACS), e.g., FACSAria Fusion	BD	N/A
Microscope with 20× and 40× magnification	N/A	N/A
NanoDrop	N/A	N/A