Table 1.
Immunological parameters
| Parameter | Patient (9 years) | Normal reference values |
|---|---|---|
| WBC (cells/μL) | 2.41 | 4.31–11.00 |
| ANC (cells/μL) | 1.72 | 1.63–7.55 |
| ALC (cells/μL) | 0.29 | 0.97–3.96 |
| CD3+ (cells/μL) | 122 | 651–2804 |
| CD4+ (cells/μL) | 68 | 370–1336 |
| Naïve CD4+ CD45RA+ CD62L+ (cells/μL) | 20 | 87–796 |
| CM CD4+ CD45RA− CD62L+ (cells/μL) | 35 | 166–544 |
| EM CD4+ CD45RA− CD62L− (cells/μL) | 13 | 80–262 |
| CD8+ (cells/μL) | 39 | 185–1024 |
| Naïve CD8+ CD45RA+ CD62L+ (cells/μL) | 18 | 37–484 |
| CM CD8+ CD45RA− CD62L+ (cells/μL) | 4 | 19–175 |
| EM CD8+ CD45RA− CD62L− (cells/μL) | 14 | 47–383 |
| TEMRA CD8+ CD45RA+ CD62L− (cells/μL) | 2 | 17–274 |
| Treg (CD4+ CD25hi FOXP3+) (cells/μL) | 13 | 27–122 |
| CD20+ (cells/μL) | 143 | 79–399 |
| CD3− CD16/56+ (cells/μL) | 24 | 126–481 |
| IgG (mg/dL) | 742* | 572–1474 |
| IgA (mg/dL) | 19 | 34–305 |
| IgM (mg/dL) | 12 | 32–208 |
| IgE (IU/mL) | 3.8 | 1.18–5.33 |
ALC, absolute lymphocyte count; ANC, absolute neutrophil count; CM, central memory; EM, effector memory, TEMRA, effector memory CD45RA+ T cells; WBC, white blood cell count
*
On IVIG replacement therapy
Abnormal values are indicated in italics