Table 1.
Susceptibility of T. rubrum ATCC MYA 4438 or BR1A planktonic cells or biofilms to nitric oxide nanoparticles (NO-np), control nanoparticles (np), fluconazole (FCZ), terbinafine (TRB), or efinaconazole (EFCZ).
| Fungi/np/drugs | PLANKTONIC CELLS | BIOFILMS | ||
|---|---|---|---|---|
| T. rubrum ATCC MYA 4438 (MIC50 mg/mL) | T. rubrum BR1A (MIC50 mg/mL) | T. rubrum ATCC MYA 4438 (SMIC50 mg/mL) | T. rubrum BR1A (SMIC50 mg/mL) | |
| NO-np | 20 | 20 | >40 | 40 |
| np | – | – | – | – |
| Fluconazole | 0.008 | 0.016 | >0.512 | >0.512 |
| Terbinafine | 0.00003 | 0.000125 | > 0.032 | >0.032 |
| Efinaconazole | 0.000125 | 0.0006 | >0.320 | >0.320 |
MIC50, minimum inhibitory concentration capable of reducing at least 50% of the metabolic activities of planktonic cells; SMIC50, sessile minimum inhibitory concentration capable of reducing at least 50% of the metabolic activities of mature biofilms; mg/mL, milligrams per milliliters).