Figure 5.

Metabolic regulation of biomarker-associated pathways. Metabolites up-regulated in HPM but down-regulated in ABE_b are depicted in orange. Metabolites down-regulated in HPM but up-regulated in ABE_b are depicted in green. Undetected metabolites in this research are depicted in grey. Black boxes indicate genes that regulate metabolites. PARP, poly ADP-ribose polymerase; AMPD, adenosine monophosphate deaminase; NT5E, 5′-nucleotidase Ecto; NNMT, nicotinamide N-methyltransferase; ADA; PNP; IGK, inosine guanosine kinase; IMPP, IMP phosphatase; XDH, xanthine dehydrogenase; HGPRT, hypoxanthine phosphoribosyltransferase; GSDA, guanosine deaminase; GAH, guanine deaminase.