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. 2021 Jul 12;6(29):18610–18622. doi: 10.1021/acsomega.1c01135

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© 2021 The Authors. Published by American Chemical Society

Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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Metabolic regulation of biomarker-associated pathways. Metabolites up-regulated in HPM but down-regulated in ABE_b are depicted in orange. Metabolites down-regulated in HPM but up-regulated in ABE_b are depicted in green. Undetected metabolites in this research are depicted in grey. Black boxes indicate genes that regulate metabolites. PARP, poly ADP-ribose polymerase; AMPD, adenosine monophosphate deaminase; NT5E, 5′-nucleotidase Ecto; NNMT, nicotinamide N-methyltransferase; ADA; PNP; IGK, inosine guanosine kinase; IMPP, IMP phosphatase; XDH, xanthine dehydrogenase; HGPRT, hypoxanthine phosphoribosyltransferase; GSDA, guanosine deaminase; GAH, guanine deaminase.