Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Cocrystal structure of 4 in MMP. The compound is positioned proximal to the triad of histidines, shown at right, that coordinate the catalytic zinc (pale blue sphere). Compound 4 makes two hydrogen bonds with bound waters (red spheres) and a hydrogen bond with the backbone carbonyl of Phe241. Compound 4 is completely enclosed within the protein. The scheme at right indicates the overlapping portions of 1 and 4.
