Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 15;15:666706. doi: 10.3389/fncel.2021.666706

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Kempfle, Duro, Zhang, Amador, Kuang, Lu, Kashemirov, Edge, McKenna and Jung.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

1Aa and Ris-1Aa activate TrkC in vitro. (A) and (A′) Expression of phosphorylated TrkC (pTrkC) on SGN neurites in vitro. Neurites were stained with neuronal marker TuJ (red), and phosphorylated TrkC (green), and nuclei were labeled with DAPI (blue). Scale bar represents 10 μm. The outgrowth of 1Aa was compared to pre-treatment with a blocking anti-TrkC antibody (1Aa after anti-TrkC) or simultaneous treatment with 1Aa and anti-TrkC (1Aa + TrkC). (A′) pTrkC staining for control, Ris or Ris-1Aa of the same experiment. Images are one representative experiment of three independently performed experiments. Inlay and arrowheads in (A) and (B) mark examples of pTrkC staining. (B) Quantification of pTrkC per 100 μm. 1Aa and 1Aa+anti-TrkC were each significant compared to all other conditions (^**represents p ≤ 0.01, ^*** represents p ≤ 0.001, ^**** represents p ≤ 0.0001; n.s., not significant).