Table 4.
Sample size estimation in each database
| Country/region | Database | Number of patients in database | Number of people aged 50+* | Number of people with OP† | Number of incident hip fractures per year‡ | |||
| Women | Men | Women (22.1% of age 50+) |
Men (6.6% of age 50+) |
Women (0.45% of age 50+) |
Men (0.20% of age 50+) |
|||
| Asia-Pacific | ||||||||
| Hong Kong | Clinical Data Analysis and Reporting System | 7M | 1.5M (21%) | 1.3M (19%) | 325K | 88K | 6615 | 2660 |
| Japan | Japanese Medical Data Center | 3.9M | 418K (11%) | 550K (14%) | 92K | 36K | 1882 | 1101 |
| South Korea | Health Insurance Review and Assessment Service | 50M | 9M (18%) | 3.3M (16%) | 2M | 218K | 40 500 | 6600 |
| Taiwan | National Health Insurance Database (NHID) | 25M | 3.5M (14%) | 3.5M (14%) | 774K | 231K | 15 750 | 7000 |
| Australia | Linked hospital databases in the State of Victoria | 90 000 hip fracture episodes | (17%) | (16%) | – | – | – | – |
| New Zealand | Ministry of Health national databases | 36 000 episodes of care | (70%) | (30%) | – | – | – | – |
| Thailand | Hospital databases or central data from National Health Security Office | 47M | 8.8M (19%) | 7.4M (16%) | 1.9M | 485K | 39 608 | 14 705 |
| Singapore | Singapore Ministry of Health Central Claims Processing System | TBD | (16%) | (17%) | ||||
| Western Europe | ||||||||
| UK | Clinical Practice Research Datalink | 4.6M | 874K (19%) | 782K (17%) | 193K | 52K | 3933 | 1564 |
| Netherlands | Integrated Primary Care Information database | 2.4M | 480K (20%) | 432K (18%) | 106K | 29K | 2160 | 864 |
| Italy | Pool of databases from 5 different regions (Lazio, Napoli, Umbria, Piemonte, Marche | 10M | 2.3M (23%) | 1.9M (19%) | 508K | 125K | 10 350 | 3800 |
| Germany | German sickness funds (WIG2) | 4.5M | 1.0M (23%) | 0.9M (20%) | 229K | 59K | 4658 | 1800 |
| Spain | Spanish Centralized Hospital Discharge Database | TBC | 1.2M (20%) | 1.02 (17%) | ||||
| France | SNDS | 66M | 14M (21%) | 11M (17%) | 3.1M | 0.74M | 63 000 | 22 440 |
| Northern Europe | ||||||||
| Denmark | Danish National Prescription Registry, Danish National Patient Register | 5.8M | 1.2M (20%) | 1.0M (18%) | 256K | 69K | 5220 | 2088 |
| Finland | Finnish Prescription Register, Care Register for Health Care, Causes of Death Register | 5.4M | 1.2M (22%) | 1.0M (19%) | 264K | 68K | 5346 | 2052 |
| South & North America | ||||||||
| Brazil | DATASUS | 209M | 25M (12%) | 21M (10%) | 5.5M | 1.4M | 1.1M | 0.4M |
| Canada | The Canadian Chronic Disease Surveillance System | 36.7M | 7.3M | 6.8M | 1.6M | 450K | 32K | 13K |
| USA | Medicare fee-for-service 20% | TBD | (18%) | (16%) | ||||
| USA | Optum | TBD | (18%) | (16%) | ||||
*Proportions taken from 2015 data from https://www.populationpyramid.net/.
†Based on Hernlund et al, Archives of OP 2013. Table 24 Estimated number of men and women with osteoporosis (defined as a T-score of −2.5 SD or less at the femoral neck) and prevalence in the population aged over 50 years in the EU27, 2010.
‡Based on Hernlund et al, Archives of OP 2013. Table 27: Estimated number of incident fractures stratified by age and fracture type in the EU27, 2010.
DATASUS, Brazilian Ministry of Health databases; SNDS, French administrative health care database; TBC, to be confirmed; TBD, to be determined.