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. 2021 Jul 15;11:626663. doi: 10.3389/fonc.2021.626663

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Copyright © 2021 Zhan, Gao, Wang, Li, Shen, Lu, Xu, Li and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The relationship between ASF1B and tumor immune infiltration. (A) The expression of ASF1B was positively correlated with B cell, CD8+ T cell, CD4+ T cell, macrophage, neutrophil and dendritic cell immune infiltration levels in HCC. (B–G) The expression levels of CD86, CD8, CD68, STAT1, STAT4 and PD1 significantly reduced in HepG2 and Huh-7 cells by ASF1B knockdown. (H) HepG2 cell was transfected with SNHG3 pcDNA or si-ASF1B, and examined for the percentage of PD-1-positive cells. *p < 0.05, **p < 0.01, ***p < 0.001.