Table 8. IC50 Values of All Compounds on DL, EAC, and PBMC Cell Linesa.
| IC50 (μM) |
|||||||
|---|---|---|---|---|---|---|---|
| cells | cisplatin | 3 | 7 | 8 | 9 | 10 | 11 |
| DL cells | 0.19 ± 0.07 | 112 ± 3.4 | 93 ± 2.8 | 8.3 ± 0.05 | 1.7 ± 0.06 | 15.8 ± 0.05 | 63.7 ± 1.3 |
| SI PBMC/DL | 79.15 | 1.33 | 4.28 | 19.42 | 82.88 | 9.18 | 6.72 |
| EAC cells | 0.37 ± 0.10 | 122.8 ± 2.8 | 103.8 ± 0.82 | 18.2 ± 0.05 | 13.7 ± 0.03 | 21.4 ± 0.57 | 87.3 ± 1.6 |
| SI PBMC/EAC | 40.64 | 1.22 | 3.83 | 8.86 | 10.28 | 6.78 | 4.90 |
| PBMCs | 15.04 ± 0.05 | 149.9 ± 1.2 | 397.6 ± 3.5 | 161.2 ± 2.8 | 140.9 ± 1.5 | 145.1 ± 1.8 | 428.1 ± 3.1 |
Dose–response curves were used for the calculation of IC50. SI refers to the selectivity index computed by IC50 (PBMC)/IC50 (DL or EAC).