Table 9. Pharmacokinetic and Druglikeness Properties of Synthesized Compounds (3 and 7–11).

	compounds
pharmacokinetic properties	3	7	8	9	10	11
GI absorption	high	high	high	high	high	high
BBB permeant	no	no	no	no	no	no
P-gp substrate	yes	yes	yes	yes	yes	yes
CYP1A2 inhibitor	no	no	no	no	no	no
CYP2C19 inhibitor	no	no	no	no	no	no
CYP2D6 inhibitor	yes	no	no	no	no	yes
CYP3A4 inhibitor	no	yes	no	no	yes	yes
water solubility	no	yes	yes	yes	yes	no

	compounds
druglikeness	3	7	8	9	10	11
Lipinski	no	yes	yes	yes	yes	no
Ghose	yes	yes	yes	yes	yes	yes
Veber	yes	yes	yes	yes	yes	yes
Egan	yes	no	yes	yes	yes	no
Muegge	yes	no	yes	yes	yes	yes