Table 2. In Vitro AChE Inhibitory Potency of Compounds 8, 10, 12–21, 23, and 28–33 and Donepezil.

compound no.	R	R′/Ar	IC50 (nM)a	relative potency (%)
8	CH3	4-CH3C6H4	500.56 ± 14	10.99
10	CH3	3,4-(CH3O)2C6H3	103.24 ± 2.8	53.27
12	CH3	2,4-Cl2C6H3	335.79 ± 9.1	16.38
13	CH3	thiophen-2-yl	173.75 ± 4.7	31.66
14	CH3	5-bromothiophen-2-yl	379.81 ± 10	14.48
15	OCH3	4-CH3C6H4	374.70 ± 10	14.68
16	OCH3	4-CH3OC6H4	108.94 ± 3	50.49
17	OCH3	3,4-(CH3O)2C6H3	175.93 ± 4.8	31.26
18	OCH3	4-ClC6H4	193.48 ± 5.3	28.43
19	OCH3	2,4-Cl2C6H3	731.33 ± 20	7.52
20	OCH3	thiophen-2-yl	259.64 ± 7.1	21.18
21	OCH3	5-bromothiophen-2-yl	187.83 ± 5.1	29.28
23			151.0 ± 4.1	36.42
28	CH3	CH3	478.20 ± 13	11.50
29	CH3	C6H5	187.86 ± 5.1	29.28
30	OCH3	CH3	346.40 ± 9.4	15.88
31	OCH3	C6H5	152.45 ± 4.1	36.08
32		3,4-(CH3O)2C6H3	450.4 ± 12	12.21
33		2,4-Cl2C6H3	187.9 ± 5.1	29.27
donepezil			55.0 ± 0.004	100

^aValues are expressed as the mean ± standard error of the mean of three experiments.