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. 2021 Jul 19;6(29):19202–19211. doi: 10.1021/acsomega.1c02549

Table 2. In Vitro AChE Inhibitory Potency of Compounds 8, 10, 12–21, 23, and 28–33 and Donepezil.

compound no. R R′/Ar IC50 (nM)a relative potency (%)
8 CH3 4-CH3C6H4 500.56 ± 14 10.99
10 CH3 3,4-(CH3O)2C6H3 103.24 ± 2.8 53.27
12 CH3 2,4-Cl2C6H3 335.79 ± 9.1 16.38
13 CH3 thiophen-2-yl 173.75 ± 4.7 31.66
14 CH3 5-bromothiophen-2-yl 379.81 ± 10 14.48
15 OCH3 4-CH3C6H4 374.70 ± 10 14.68
16 OCH3 4-CH3OC6H4 108.94 ± 3 50.49
17 OCH3 3,4-(CH3O)2C6H3 175.93 ± 4.8 31.26
18 OCH3 4-ClC6H4 193.48 ± 5.3 28.43
19 OCH3 2,4-Cl2C6H3 731.33 ± 20 7.52
20 OCH3 thiophen-2-yl 259.64 ± 7.1 21.18
21 OCH3 5-bromothiophen-2-yl 187.83 ± 5.1 29.28
23     151.0 ± 4.1 36.42
28 CH3 CH3 478.20 ± 13 11.50
29 CH3 C6H5 187.86 ± 5.1 29.28
30 OCH3 CH3 346.40 ± 9.4 15.88
31 OCH3 C6H5 152.45 ± 4.1 36.08
32   3,4-(CH3O)2C6H3 450.4 ± 12 12.21
33   2,4-Cl2C6H3 187.9 ± 5.1 29.27
donepezil     55.0 ± 0.004 100
a

Values are expressed as the mean ± standard error of the mean of three experiments.